ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Cpe

Full Name:

carboxypeptidase E

Alias:

CARBE|Cph|MGC93638

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

16p13

Physical Location:

26748679-26749044 on NC_005115.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1363 Symbol (Name): CPE (carboxypeptidase E)

Ortholog Status:

The human GeneID 1363 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		25669
Fold Change:		0.922
P Value:		<0.001
Note:		Fold change is average ratio of AA to ANA.

Dataset Information

Name:		15846778
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:		DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
XM_001074218.1	XP_001074218.1	NC_005115.2 range: 26748679..26749044

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005624	membrane fraction	Cellular Component	IDA (8626393)
GO:0030141	secretory granule	Cellular Component	IDA (2822027)
GO:0005794	Golgi apparatus	Cellular Component	IDA (9173892)
GO:0005615	extracellular space	Cellular Component	IDA (10206965)
GO:0005625	soluble fraction	Cellular Component	IDA (8626393)
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0008237	metallopeptidase activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0050897	cobalt ion binding	Molecular Function	IMP (2822027)
GO:0004180	carboxypeptidase activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (16219686)
GO:0004183	carboxypeptidase E activity	Molecular Function	TAS (2784437)
GO:0004183	carboxypeptidase E activity	Molecular Function	ISS
GO:0004183	carboxypeptidase E activity	Molecular Function	IEA
GO:0004183	carboxypeptidase E activity	Molecular Function	IDA (16219686)
GO:0004182	carboxypeptidase A activity	Molecular Function	IEA
GO:0030070	insulin processing	Biological Process	ISS
GO:0030070	insulin processing	Biological Process	IDA (2822027)
GO:0016486	peptide hormone processing	Biological Process	TAS (2784437)
GO:0006518	peptide metabolic process	Biological Process	IDA (16219686)
GO:0006508	proteolysis	Biological Process	IEA
GO:0051605	protein maturation via proteolysis	Biological Process	IDA (2822027)