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Gene Information
Gene ID:25669
Full Name:carboxypeptidase E
Organism:Rattus norvegicus (Rat)
Genetic Location:16p13
Physical Location:26748679-26749044 on NC_005115.2
Gene Type:protein-coding
Human Ortholog:GeneID: 1363    Symbol (Name): CPE (carboxypeptidase E)
Ortholog Status:The human GeneID 1363 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:25669
Fold Change:0.922
P Value:<0.001
Note:Fold change is average ratio of AA to ANA.
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
XM_001074218.1XP_001074218.1NC_005115.2 range: 26748679..26749044
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005624membrane fractionCellular ComponentIDA (8626393)
GO:0030141secretory granuleCellular ComponentIDA (2822027)
GO:0005794Golgi apparatusCellular ComponentIDA (9173892)
GO:0005615extracellular spaceCellular ComponentIDA (10206965)
GO:0005625soluble fractionCellular ComponentIDA (8626393)
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0008237metallopeptidase activityMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0050897cobalt ion bindingMolecular FunctionIMP (2822027)
GO:0004180carboxypeptidase activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (16219686)
GO:0004183carboxypeptidase E activityMolecular FunctionTAS (2784437)
GO:0004183carboxypeptidase E activityMolecular FunctionISS
GO:0004183carboxypeptidase E activityMolecular FunctionIEA
GO:0004183carboxypeptidase E activityMolecular FunctionIDA (16219686)
GO:0004182carboxypeptidase A activityMolecular FunctionIEA
GO:0030070insulin processingBiological ProcessISS
GO:0030070insulin processingBiological ProcessIDA (2822027)
GO:0016486peptide hormone processingBiological ProcessTAS (2784437)
GO:0006518peptide metabolic processBiological ProcessIDA (16219686)
GO:0006508proteolysisBiological ProcessIEA
GO:0051605protein maturation via proteolysisBiological ProcessIDA (2822027)
Other Database Cross Links
NCBI Entrez Gene:25669