ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ddx5

Full Name:

DEAD (Asp-Glu-Ala-Asp) box polypeptide 5

Alias:

2600009A06Rik|G17P1|HUMP68|Hlr1|MGC118083|p68

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

11 E2|11 63.0 cM

Physical Location:

106641669-106649807 on NC_000077.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1655 Symbol (Name): DDX5 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 5)

Ortholog Status:

The human GeneID 1655 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Ddx5
Original ID2:		X65627

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007840.3	NP_031866.2	NC_000077.5 range: 106641669..106649807, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IC (15464984)
GO:0005681	spliceosome	Cellular Component	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0008026	ATP-dependent helicase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (15464984)
GO:0004386	helicase activity	Molecular Function	IEA
GO:0003723	RNA binding	Molecular Function	IEA
GO:0003712	transcription cofactor activity	Molecular Function	IDA (15464984)
GO:0003676	nucleic acid binding	Molecular Function	IEA
GO:0006397	mRNA processing	Biological Process	IEA
GO:0008380	RNA splicing	Biological Process	IEA
GO:0045941	positive regulation of transcription	Biological Process	IDA (15464984)