ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

DDX5

Full Name:

DEAD (Asp-Glu-Ala-Asp) box polypeptide 5

Alias:

DKFZp686J01190|G17P1|HLR1|HUMP68|p68

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17q21

Physical Location:

59926199-59932868 on NC_000017.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 13207 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.279806
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Information

Original ID1:

DDX5

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_004396.2	NP_004387.1	NC_000017.9 range: 59926199..59932868, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005681	spliceosome	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	NAS (2451786)
GO:0008026	ATP-dependent helicase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (17220478\|17353931)
GO:0003724	RNA helicase activity	Molecular Function	NAS (1996094)
GO:0003723	RNA binding	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0006397	mRNA processing	Biological Process	IEA
GO:0008380	RNA splicing	Biological Process	IEA
GO:0016049	cell growth	Biological Process	NAS (2451786)