ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CREM

Full Name:

cAMP responsive element modulator

Alias:

ICER|MGC111110|MGC17881|MGC41893|hCREM-2

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

10p11.21

Physical Location:

35455806-35541891 on NC_000010.9

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 25620 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

AL117336

Dataset Information

Name:		12065639
Method:		Microarray
Tissue:		Frontal and motor cortices
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
Summary:		We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. Fluorescent intensity ratios of 1.4-fold or greater in either direction (representing the 99% confidence interval) were used to indicate differentially expressed genes.

Gene Information

Original ID1:

CREM

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	NAS (8206879)
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0008140	cAMP response element binding protein binding	Molecular Function	NAS (8206879)
GO:0046983	protein dimerization activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IDA (8206879)
GO:0007165	signal transduction	Biological Process	TAS (7916662)
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0007283	spermatogenesis	Biological Process	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0030154	cell differentiation	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	NAS (7916662)