ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Crem

Full Name:

cAMP responsive element modulator

Alias:

Icer

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

17q12.1

Physical Location:

62782415-62836429 on NC_005116.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1390 Symbol (Name): CREM (cAMP responsive element modulator)

Ortholog Status:

The human GeneID 1390 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Crem
Fold Change:		1.15
P Value:		0.001
Note:		Differential expression between ethanol and saccharin groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	ISS
GO:0005667	transcription factor complex	Cellular Component	ISS
GO:0003677	DNA binding	Molecular Function	ISS
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0046983	protein dimerization activity	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0042752	regulation of circadian rhythm	Biological Process	IEP (15936880)
GO:0019933	cAMP-mediated signaling	Biological Process	TAS (7809053)
GO:0007283	spermatogenesis	Biological Process	ISS
GO:0006631	fatty acid metabolic process	Biological Process	IEP (14534319)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	TAS (7809053)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	ISS
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006006	glucose metabolic process	Biological Process	IEP (14534319)
GO:0048384	retinoic acid receptor signaling pathway	Biological Process	IEP (15725648)