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Gene Information
Gene ID:25620
Full Name:cAMP responsive element modulator
Organism:Rattus norvegicus (Rat)
Genetic Location:17q12.1
Physical Location:62782415-62836429 on NC_005116.2
Gene Type:protein-coding
Human Ortholog:GeneID: 1390    Symbol (Name): CREM (cAMP responsive element modulator)
Ortholog Status:The human GeneID 1390 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Crem
Fold Change:1.15
P Value:0.001
Note:Differential expression between ethanol and saccharin groups in amygdala
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_013086.1NP_037218.1NC_005116.2 range: 62782415..62836429
NM_017334.1NP_059030.1NC_005116.2 range: 62782415..62836429
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0005634nucleusCellular ComponentISS
GO:0005667transcription factor complexCellular ComponentISS
GO:0003677DNA bindingMolecular FunctionISS
GO:0043565sequence-specific DNA bindingMolecular FunctionIEA
GO:0046983protein dimerization activityMolecular FunctionIEA
GO:0003700transcription factor activityMolecular FunctionIEA
GO:0042752regulation of circadian rhythmBiological ProcessIEP (15936880)
GO:0019933cAMP-mediated signalingBiological ProcessTAS (7809053)
GO:0007283spermatogenesisBiological ProcessISS
GO:0006631fatty acid metabolic processBiological ProcessIEP (14534319)
GO:0006355regulation of transcription, DNA-dependentBiological ProcessTAS (7809053)
GO:0006355regulation of transcription, DNA-dependentBiological ProcessISS
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0006006glucose metabolic processBiological ProcessIEP (14534319)
GO:0048384retinoic acid receptor signaling pathwayBiological ProcessIEP (15725648)
Other Database Cross Links
NCBI Entrez Gene:25620