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Gene Information
Gene ID:1395
Full Name:corticotropin releasing hormone receptor 2
Organism:Homo sapiens (Human)
Genetic Location:7p15.1
Physical Location:30659387-30688664 on NC_000007.12, complement
Gene Type:protein-coding
Orthologs:This gene has Rat: 64680 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:CRHR2
Dataset Information
Method:Addiction array gene list
Publication:Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
Summary:To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.
Gene Information
Original ID1:CRHR2
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001883.3NP_001874.2NC_000007.12 range: 30659387..30688664, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005886plasma membraneCellular ComponentTAS (8536644)
GO:0005887integral to plasma membraneCellular ComponentTAS (8536644)
GO:0004872receptor activityMolecular FunctionIEA
GO:0004930G-protein coupled receptor activityMolecular FunctionIEA
GO:0015056corticotrophin-releasing factor receptor activityMolecular FunctionTAS (9717834)
GO:0007165signal transductionBiological ProcessIEA
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessIEA
GO:0007188G-protein signaling, coupled to cAMP nucleotide second messengerBiological ProcessTAS (8536644)
Other Database Cross Links
NCBI Entrez Gene:1395
HuGE Navigator:1395