Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:64680
Full Name:corticotropin releasing hormone receptor 2
Organism:Rattus norvegicus (Rat)
Genetic Location:4q24
Physical Location:83839821-83867016 on NC_005103.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 1395    Symbol (Name): CRHR2 (corticotropin releasing hormone receptor 2)
Ortholog Status:The human GeneID 1395 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:64680
Fold Change:1.56
P Value:0.044
Note:Fold change is average ratio of AA to ANA.
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_022714.1NP_073205.1NC_005103.2 range: 83839821..83867016, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentIMP (7846062)
GO:0016020membraneCellular ComponentIEA
GO:0004930G-protein coupled receptor activityMolecular FunctionIEA
GO:0043404corticotropin-releasing hormone receptor activityMolecular FunctionIDA (12942143)
GO:0017047adrenocorticotropin-releasing hormone bindingMolecular FunctionIDA (7846062)
GO:0015056corticotrophin-releasing factor receptor activityMolecular FunctionISS
GO:0051424corticotropin-releasing hormone bindingMolecular FunctionIDA (12942143)
GO:0005515protein bindingMolecular FunctionISS
GO:0005179hormone activityMolecular FunctionISS
GO:0004978adrenocorticotropin receptor activityMolecular FunctionIDA (7846062)
GO:0004930G-protein coupled receptor activityMolecular FunctionTAS (11784785)
GO:0007188G-protein signaling, coupled to cAMP nucleotide second messengerBiological ProcessIDA (7846062)
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessISS
GO:0016525negative regulation of angiogenesisBiological ProcessISS
GO:0007631feeding behaviorBiological ProcessNAS (12446596)
Other Database Cross Links
NCBI Entrez Gene:64680