ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Crhr2

Full Name:

corticotropin releasing hormone receptor 2

Alias:

Crf2r

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

4q24

Physical Location:

83839821-83867016 on NC_005103.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1395 Symbol (Name): CRHR2 (corticotropin releasing hormone receptor 2)

Ortholog Status:

The human GeneID 1395 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		64680
Fold Change:		1.56
P Value:		0.044
Note:		Fold change is average ratio of AA to ANA.

Dataset Information

Name:		15846778
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:		DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_022714.1	NP_073205.1	NC_005103.2 range: 83839821..83867016, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IMP (7846062)
GO:0016020	membrane	Cellular Component	IEA
GO:0004930	G-protein coupled receptor activity	Molecular Function	IEA
GO:0043404	corticotropin-releasing hormone receptor activity	Molecular Function	IDA (12942143)
GO:0017047	adrenocorticotropin-releasing hormone binding	Molecular Function	IDA (7846062)
GO:0015056	corticotrophin-releasing factor receptor activity	Molecular Function	ISS
GO:0051424	corticotropin-releasing hormone binding	Molecular Function	IDA (12942143)
GO:0005515	protein binding	Molecular Function	ISS
GO:0005179	hormone activity	Molecular Function	ISS
GO:0004978	adrenocorticotropin receptor activity	Molecular Function	IDA (7846062)
GO:0004930	G-protein coupled receptor activity	Molecular Function	TAS (11784785)
GO:0007188	G-protein signaling, coupled to cAMP nucleotide second messenger	Biological Process	IDA (7846062)
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	ISS
GO:0016525	negative regulation of angiogenesis	Biological Process	ISS
GO:0007631	feeding behavior	Biological Process	NAS (12446596)