ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Fosb

Full Name:

FBJ osteosarcoma oncogene B

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

7 A2-B1|7 5.0 cM

Physical Location:

19888044-19895393 on NC_000073.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2354 Symbol (Name): FOSB (FBJ murine osteosarcoma viral oncogene homolog B)

Ortholog Status:

The human GeneID 2354 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Fosb
Original ID2:		X14897

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008036.2	NP_032062.1	NC_000073.5 range: 19888044..19895393, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0003677	DNA binding	Molecular Function	IDA (12220541)
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0046983	protein dimerization activity	Molecular Function	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA