ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

FOSB

Full Name:

FBJ murine osteosarcoma viral oncogene homolog B

Alias:

AP-1|DKFZp686C0818|G0S3|GOS3|GOSB|MGC42291

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

19q13.32

Physical Location:

50663092-50670275 on NC_000019.8

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 14282 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

NM_006732

Dataset Information

Name:		12065639
Method:		Microarray
Tissue:		Frontal and motor cortices
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
Summary:		We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. Fluorescent intensity ratios of 1.4-fold or greater in either direction (representing the 99% confidence interval) were used to indicate differentially expressed genes.

Gene Information

Original ID1:

FOSB

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_006732.2	NP_006723.2	NC_000019.8 range: 50663092..50670275

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0008134	transcription factor binding	Molecular Function	TAS (1900040)
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0046983	protein dimerization activity	Molecular Function	IEA
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	TAS (1900040)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0007275	multicellular organismal development	Biological Process	TAS (8706134)
GO:0007610	behavior	Biological Process	TAS (8706134)