Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:14580
Full Name:glial fibrillary acidic protein
Organism:Mus musculus (Mouse)
Genetic Location:11 D|11 62.0 cM
Physical Location:102749990-102758444 on NC_000077.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 2670    Symbol (Name): GFAP (glial fibrillary acidic protein)
Ortholog Status:The human GeneID 2670 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Gfap
Original ID2:X02801
Dataset Information
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_010277.2NP_034407.2NC_000077.5 range: 102749990..102758444, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005624membrane fractionCellular ComponentIDA (11283023)
GO:0005737cytoplasmCellular ComponentIDA (15965470)
GO:0005882intermediate filamentCellular ComponentIDA (12533615|12878680|15656993)
GO:0005198structural molecule activityMolecular FunctionIMP (12177195)
GO:0005515protein bindingMolecular FunctionIPI (12403814)
GO:0045103intermediate filament-based processBiological ProcessIMP (12177195)
Other Database Cross Links
NCBI Entrez Gene:14580