ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gfap

Full Name:

glial fibrillary acidic protein

Alias:

AI836096

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

11 D|11 62.0 cM

Physical Location:

102749990-102758444 on NC_000077.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2670 Symbol (Name): GFAP (glial fibrillary acidic protein)

Ortholog Status:

The human GeneID 2670 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Gfap
Original ID2:		X02801

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_010277.2	NP_034407.2	NC_000077.5 range: 102749990..102758444, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005624	membrane fraction	Cellular Component	IDA (11283023)
GO:0005737	cytoplasm	Cellular Component	IDA (15965470)
GO:0005882	intermediate filament	Cellular Component	IDA (12533615\|12878680\|15656993)
GO:0005198	structural molecule activity	Molecular Function	IMP (12177195)
GO:0005515	protein binding	Molecular Function	IPI (12403814)
GO:0045103	intermediate filament-based process	Biological Process	IMP (12177195)