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Gene Information
Gene ID:14806
Symbol:Grik2
Full Name:glutamate receptor, ionotropic, kainate 2 (beta 2)
Alias:AW124492|Glur-6|Glur6
Organism:Mus musculus (Mouse)
Chromosome:10
Genetic Location:10 B3|10 27.0 cM
Physical Location:48820794-49503214 on NC_000076.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 2898    Symbol (Name): GRIK2 (glutamate receptor, ionotropic, kainate 2)
Ortholog Status:The human GeneID 2898 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:X66117
Note:Differences expression in alcohol-preferring and alcohol-nonpreferring mouse strains
Dataset Information
Name:15282116
Method:Microarray
Tissue:Striata
Phenotype:Alcohol-nonpreferring, alcohol-preferring, alcohol self-administration
Publication:Saito et al. Alcohol. (2004) Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. PubMed
Summary:Aiming to define pathways among genomic, neural, and behavioral determinants of addiction, we investigated global striatal gene expression in a paradigm of oral self-administration of alcohol by using genomically very similar alcohol-nonpreferring B6.Cb(5)i(7)-alpha 3/Vad (C5A3) and alcohol-preferring B6.Ib(5)i(7)-beta 25A/Vad (I5B25A) quasi-congenic mouse strains and their progenitors, C57BL/6By (B6By) and BALB/cJ. Expression of 12,488 genes and expressed sequence tags (ESTs) was studied by using 24 high-density oligonucleotide microarrays. As expected, striatal transcriptome differences were far more extensive between the independently derived progenitor strains than between the quasi-congenic strains and their background partner, B6By.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_010349.2NP_034479.2NC_000076.5 range: 48820794..49503214, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0042734presynaptic membraneCellular ComponentIDA (11985817|14724198)
GO:0016021integral to membraneCellular ComponentRCA (12466851)
GO:0016020membraneCellular ComponentIDA (15014126)
GO:0016020membraneCellular ComponentIEA
GO:0045211postsynaptic membraneCellular ComponentIEA
GO:0030054cell junctionCellular ComponentIEA
GO:0032983kainate selective glutamate receptor complexCellular ComponentIPI (12954862|17174564)
GO:0045211postsynaptic membraneCellular ComponentIDA (14724198)
GO:0045202synapseCellular ComponentTAS (16354929)
GO:0043025cell somaCellular ComponentIDA (9141074)
GO:0008328ionotropic glutamate receptor complexCellular ComponentIC (12223554)
GO:0005615extracellular spaceCellular ComponentRCA (12466851)
GO:0005624membrane fractionCellular ComponentIDA (12954862)
GO:0015277kainate selective glutamate receptor activityMolecular FunctionIDA (1310861|12151522|15483117)
GO:0005234extracellular-glutamate-gated ion channel activityMolecular FunctionIEA
GO:0015277kainate selective glutamate receptor activityMolecular FunctionIMP (9580260|9880586|10704492|11985817|12223554|15509753)
GO:0015277kainate selective glutamate receptor activityMolecular FunctionIGI (1310861|11985817)
GO:0005216ion channel activityMolecular FunctionIEA
GO:0004970ionotropic glutamate receptor activityMolecular FunctionIEA
GO:0004872receptor activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (12954862|15805114|16354929|17174564)
GO:0043524negative regulation of neuron apoptosisBiological ProcessIGI (10479699)
GO:0048169regulation of long-term neuronal synaptic plasticityBiological ProcessIMP (11182092|12947409|15673679|16219388)
GO:0060080regulation of inhibitory postsynaptic membrane potentialBiological ProcessIMP (9880586|10704492|12223554)
GO:0060080regulation of inhibitory postsynaptic membrane potentialBiological ProcessIGI (10704492|11144357)
GO:0060079regulation of excitatory postsynaptic membrane potentialBiological ProcessIMP (11069933|14724198|17428973)
GO:0048172regulation of short-term neuronal synaptic plasticityBiological ProcessIMP (11182092)
GO:0051967negative regulation of synaptic transmission, glutamatergicBiological ProcessIGI (11985817)
GO:0060079regulation of excitatory postsynaptic membrane potentialBiological ProcessIGI (11985817|17428973)
GO:0042391regulation of membrane potentialBiological ProcessIMP (9490692|10704492|12223554|15509753|15513934|16219388)
GO:0006811ion transportBiological ProcessIEA
GO:0006874cellular calcium ion homeostasisBiological ProcessIMP (16219388)
GO:0006886intracellular protein transportBiological ProcessIDA (15014126)
GO:0007268synaptic transmissionBiological ProcessIGI (15928066)
GO:0007268synaptic transmissionBiological ProcessIMP (15928066)
GO:0001662behavioral fear responseBiological ProcessIMP (15673679)
GO:0019228regulation of action potential in neuronBiological ProcessIMP (15539395)
GO:0035249synaptic transmission, glutamatergicBiological ProcessIMP (9580260|15509753)
GO:0042391regulation of membrane potentialBiological ProcessIDA (1310861|12151522)
GO:0042391regulation of membrane potentialBiological ProcessIGI (1310861)
GO:0006810transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:14806
MGI:
Ensembl:ENSMUSG00000056073
dbSNP:Grik2
AceView:Grik2