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Gene Information
Gene ID:1621
Symbol:DBH
Full Name:dopamine beta-hydroxylase (dopamine beta-monooxygenase)
Alias:DBM
Organism:Homo sapiens (Human)
Chromosome:9
Genetic Location:9q34
Physical Location:135491305-135514286 on NC_000009.10
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:DBH
Original ID2:X13255
Dataset Information
Name:11093800
Method:Microarray
Tissue:SH-SY5Y neuroblastoma cells
Phenotype:Ethanol response
Publication:Thibault et al. Mol Pharmacol. (2000) Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression. PubMed
Summary:We used oligonucleotide arrays to study nearly 6000 genes in human SH-SY5Y neuroblastoma cells exposed to chronic ethanol. A set of 42 genes had consistently increased or decreased mRNA abundance after 3 days of ethanol treatment.
Gene Information
Original ID1:DBH
Dataset Information
Name:18477577
Method:Addiction array gene list
Publication:Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
Summary:To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.
Gene Information
Original ID1:DBH
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Information
Original IDNo. of PublicationsPhenotype
DBH2Alcohol-Induced Disorders
DBH2Alcohol-Induced Disorders Nervous System
DBH5Alcoholism
DBH4Alcohol-Related Disorders
DBH2Alcohol Withdrawal Delirium
HuGE Navigator Dataset
Name:HuGE Navigator
Method:Literature data mining
Publication:Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000787.3NP_000778.3NC_000009.10 range: 135491305..135514286
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0031410cytoplasmic vesicleCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentTAS (3443096)
GO:0005625soluble fractionCellular ComponentTAS (3443096)
GO:0005624membrane fractionCellular ComponentTAS (3443096)
GO:0005576extracellular regionCellular ComponentNAS (14718574)
GO:0042583chromaffin granuleCellular ComponentNAS
GO:0031418L-ascorbic acid bindingMolecular FunctionIEA
GO:0004497monooxygenase activityMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0005507copper ion bindingMolecular FunctionIEA
GO:0004500dopamine beta-monooxygenase activityMolecular FunctionIEA
GO:0009987cellular processBiological ProcessIEA
GO:0006548histidine catabolic processBiological ProcessIEA
GO:0042423catecholamine biosynthetic processBiological ProcessIEA
GO:0007268synaptic transmissionBiological ProcessTAS (2880016)
Other Database Cross Links
NCBI Entrez Gene:1621
HGNC:2689
Ensembl:ENSG00000123454
MIM:609312
HPRD:01963
HuGE Navigator:1621
dbSNP:DBH
GeneCard:DBH
AceView:DBH