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Gene Information
Gene ID:16531
Symbol:Kcnma1
Full Name:potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Alias:MaxiK|Slo|Slo1|mSlo|mSlo1
Organism:Mus musculus (Mouse)
Chromosome:14
Genetic Location:14 A3
Physical Location:24117982-24823426 on NC_000080.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 3778    Symbol (Name): KCNMA1 (potassium large conductance calcium-activated channel, subfamily M, alpha member 1)
Ortholog Status:The human GeneID 3778 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Kcnma1
Original ID2:U09383
Dataset Information
Name:15745951
Method:Microarray
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_010610.2NP_034740.2NC_000080.5 range: 24117982..24823426, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0005783endoplasmic reticulumCellular ComponentIDA (17303127)
GO:0016021integral to membraneCellular ComponentIC (7687074)
GO:0016021integral to membraneCellular ComponentIDA (12388098)
GO:0016021integral to membraneCellular ComponentRCA (16141072)
GO:0016324apical plasma membraneCellular ComponentIDA (17135251)
GO:0043195terminal buttonCellular ComponentIDA (15328414)
GO:0044444cytoplasmic partCellular ComponentIDA (12952984)
GO:0045211postsynaptic membraneCellular ComponentIDA (15328414)
GO:0009897external side of plasma membraneCellular ComponentIDA (17303127)
GO:0008076voltage-gated potassium channel complexCellular ComponentIGI (12388098)
GO:0005886plasma membraneCellular ComponentIDA (10517674|12952984)
GO:0015269calcium-activated potassium channel activityMolecular FunctionIDA (7687074|10517674|16081418|16306267|17303127)
GO:0015269calcium-activated potassium channel activityMolecular FunctionIGI (12388098)
GO:0015269calcium-activated potassium channel activityMolecular FunctionIMP (15184377)
GO:0015269calcium-activated potassium channel activityMolecular FunctionRCA (16141072)
GO:0060072large conductance calcium-activated potassium channel activityMolecular FunctionIMP (16873365)
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0060072large conductance calcium-activated potassium channel activityMolecular FunctionIDA (12388098)
GO:0030955potassium ion bindingMolecular FunctionIEA
GO:0005249voltage-gated potassium channel activityMolecular FunctionIDA (7687074|16081418)
GO:0005244voltage-gated ion channel activityMolecular FunctionIEA
GO:0005216ion channel activityMolecular FunctionIEA
GO:0003824catalytic activityMolecular FunctionIEA
GO:0005249voltage-gated potassium channel activityMolecular FunctionIMP (15184377)
GO:0005267potassium channel activityMolecular FunctionIGI (16873365)
GO:0005267potassium channel activityMolecular FunctionIMP (17135251)
GO:0005488bindingMolecular FunctionIEA
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (17303127)
GO:0000287magnesium ion bindingMolecular FunctionIEA
GO:0048469cell maturationBiological ProcessIMP (15328414)
GO:0060083smooth muscle contraction involved in micturitionBiological ProcessIMP (15827347)
GO:0060082eye blink reflexBiological ProcessIMP (15194823)
GO:0045475locomotor rhythmBiological ProcessIMP (16845385)
GO:0045794negative regulation of cell volumeBiological ProcessIMP (16873365)
GO:0046541saliva secretionBiological ProcessIGI (16873365)
GO:0060073micturitionBiological ProcessIMP (15184377)
GO:0001666response to hypoxiaBiological ProcessIDA (16306267)
GO:0051260protein homooligomerizationBiological ProcessIDA (17303127)
GO:0050885neuromuscular process controlling balanceBiological ProcessIMP (15184377|15194823)
GO:0007605sensory perception of soundBiological ProcessIMP (17135251)
GO:0042491auditory receptor cell differentiationBiological ProcessIMP (15328414|17074442)
GO:0007623circadian rhythmBiological ProcessIMP (16845385)
GO:0007605sensory perception of soundBiological ProcessIMP (15328414|16763026)
GO:0007268synaptic transmissionBiological ProcessIMP (15194823)
GO:0008152metabolic processBiological ProcessIEA
GO:0006813potassium ion transportBiological ProcessIDA (7687074|10517674)
GO:0006812cation transportBiological ProcessRCA (16141072)
GO:0006811ion transportBiological ProcessIEA
GO:0006810transportBiological ProcessIEA
GO:0019228regulation of action potential in neuronBiological ProcessIMP (16845385)
GO:0007628adult walking behaviorBiological ProcessIMP (15184377|15194823)
GO:0032344regulation of aldosterone metabolic processBiological ProcessIMP (17122062)
GO:0042311vasodilationBiological ProcessIMP (15867178)
GO:0042391regulation of membrane potentialBiological ProcessIDA (7687074)
GO:0042391regulation of membrane potentialBiological ProcessIMP (15194823|16763026)
GO:0060087relaxation of vascular smooth muscleBiological ProcessIMP (15867178)
Other Database Cross Links
NCBI Entrez Gene:16531
MGI:
Ensembl:ENSMUSG00000063142
dbSNP:Kcnma1
AceView:Kcnma1