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Gene Information
Gene ID:170913
Full Name:ATP-binding cassette, sub-family B (MDR/TAP), member 1A
Organism:Rattus norvegicus (Rat)
Genetic Location:4q12
Physical Location:21709854-21796627 on NC_005103.2
Gene Type:protein-coding
Human Ortholog:GeneID: 5243    Symbol (Name): ABCB1 (ATP-binding cassette, sub-family B (MDR/TAP), member 1)
Ortholog Status:The human GeneID 5243 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Abcb1a
Fold Change:1.21
P Value:0.004
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_133401.1NP_596892.1NC_005103.2 range: 21709854..21796627
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0046581intercellular canaliculusCellular ComponentISS
GO:0016021integral to membraneCellular ComponentIEA
GO:0009986cell surfaceCellular ComponentISS
GO:0005575cellular_componentCellular ComponentND
GO:0016887ATPase activityMolecular FunctionIEA
GO:0042626ATPase activity, coupled to transmembrane movement of substancesMolecular FunctionIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIPI
GO:0003674molecular_functionMolecular FunctionND
GO:0042623ATPase activity, coupledMolecular FunctionISS
GO:0042493response to drugBiological ProcessIEP (16221289)
GO:0015893drug transportBiological ProcessISS
GO:0006810transportBiological ProcessIEA
GO:0046686response to cadmium ionBiological ProcessIEP (17136310)
Other Database Cross Links
NCBI Entrez Gene:170913