ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Abcb1a

Full Name:

ATP-binding cassette, sub-family B (MDR/TAP), member 1A

Alias:

Mdr1a

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

4q12

Physical Location:

21709854-21796627 on NC_005103.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5243 Symbol (Name): ABCB1 (ATP-binding cassette, sub-family B (MDR/TAP), member 1)

Ortholog Status:

The human GeneID 5243 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Abcb1a
Fold Change:		1.21
P Value:		0.004
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_133401.1	NP_596892.1	NC_005103.2 range: 21709854..21796627

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0046581	intercellular canaliculus	Cellular Component	ISS
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0009986	cell surface	Cellular Component	ISS
GO:0005575	cellular_component	Cellular Component	ND
GO:0016887	ATPase activity	Molecular Function	IEA
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IPI
GO:0003674	molecular_function	Molecular Function	ND
GO:0042623	ATPase activity, coupled	Molecular Function	ISS
GO:0042493	response to drug	Biological Process	IEP (16221289)
GO:0015893	drug transport	Biological Process	ISS
GO:0006810	transport	Biological Process	IEA
GO:0046686	response to cadmium ion	Biological Process	IEP (17136310)