ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ABCB1

Full Name:

ATP-binding cassette, sub-family B (MDR/TAP), member 1

Alias:

ABC20|CD243|CLCS|GP170|MDR1|MGC163296|P-gp|PGY1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

7q21.1

Physical Location:

86970883-87180499 on NC_000007.12, complement

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 170913 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		PGY1
Original ID2:		M29447

Dataset Information

Name:		11093800
Method:		Microarray
Tissue:		SH-SY5Y neuroblastoma cells
Phenotype:		Ethanol response
Publication:		Thibault et al. Mol Pharmacol. (2000) Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression. PubMed
Summary:		We used oligonucleotide arrays to study nearly 6000 genes in human SH-SY5Y neuroblastoma cells exposed to chronic ethanol. A set of 42 genes had consistently increased or decreased mRNA abundance after 3 days of ethanol treatment.

Gene Information

Original ID1:

ABCB1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Information

HuGE Navigator Dataset

Name:		HuGE Navigator
Method:		Literature data mining
Publication:		Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:		HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000927.3	NP_000918.2	NC_000007.12 range: 86970883..87180499, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	TAS (3768958)
GO:0005624	membrane fraction	Cellular Component	TAS (3022150)
GO:0016020	membrane	Cellular Component	IEA
GO:0009986	cell surface	Cellular Component	IEP (12493773)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0016887	ATPase activity	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0008559	xenobiotic-transporting ATPase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	TAS (3768958)
GO:0005515	protein binding	Molecular Function	IPI (17088979)
GO:0005215	transporter activity	Molecular Function	TAS (3022150)
GO:0006810	transport	Biological Process	TAS (3022150)
GO:0042493	response to drug	Biological Process	TAS (3022150)