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Gene Information
Gene ID:5243
Full Name:ATP-binding cassette, sub-family B (MDR/TAP), member 1
Organism:Homo sapiens (Human)
Genetic Location:7q21.1
Physical Location:86970883-87180499 on NC_000007.12, complement
Gene Type:protein-coding
Orthologs:This gene has Rat: 170913 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:PGY1
Original ID2:M29447
Dataset Information
Tissue:SH-SY5Y neuroblastoma cells
Phenotype:Ethanol response
Publication:Thibault et al. Mol Pharmacol. (2000) Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression. PubMed
Summary:We used oligonucleotide arrays to study nearly 6000 genes in human SH-SY5Y neuroblastoma cells exposed to chronic ethanol. A set of 42 genes had consistently increased or decreased mRNA abundance after 3 days of ethanol treatment.
Gene Information
Original ID1:ABCB1
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Information
Original IDNo. of PublicationsPhenotype
ABCB11Alcohol-Related Disorders
HuGE Navigator Dataset
Name:HuGE Navigator
Method:Literature data mining
Publication:Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000927.3NP_000918.2NC_000007.12 range: 86970883..87180499, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentTAS (3768958)
GO:0005624membrane fractionCellular ComponentTAS (3022150)
GO:0016020membraneCellular ComponentIEA
GO:0009986cell surfaceCellular ComponentIEP (12493773)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0016887ATPase activityMolecular FunctionIEA
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0008559xenobiotic-transporting ATPase activityMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionTAS (3768958)
GO:0005515protein bindingMolecular FunctionIPI (17088979)
GO:0005215transporter activityMolecular FunctionTAS (3022150)
GO:0006810transportBiological ProcessTAS (3022150)
GO:0042493response to drugBiological ProcessTAS (3022150)
Other Database Cross Links
NCBI Entrez Gene:5243
HuGE Navigator:5243