ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pcx

Full Name:

pyruvate carboxylase

Alias:

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

19 A|19 0.0 cM

Physical Location:

4594345-4621697 on NC_000085.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5091 Symbol (Name): PC (pyruvate carboxylase)

Ortholog Status:

The human GeneID 5091 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Pcx
Original ID2:		M97957

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008797.2	NP_032823.1	NC_000085.5 range: 4594345..4621697

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005743	mitochondrial inner membrane	Cellular Component	IDA (12865426)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005739	mitochondrion	Cellular Component	IDA (14651853)
GO:0005739	mitochondrion	Cellular Component	ISO
GO:0016874	ligase activity	Molecular Function	IEA
GO:0009374	biotin binding	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004736	pyruvate carboxylase activity	Molecular Function	IEA
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0030145	manganese ion binding	Molecular Function	IEA
GO:0006094	gluconeogenesis	Biological Process	IEA
GO:0008152	metabolic process	Biological Process	IEA
GO:0008610	lipid biosynthetic process	Biological Process	IEA