ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ppp2cb

Full Name:

protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform

Alias:

AI115466|D8Ertd766e|PP2Ac

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

8 A4|8 20.0 cM

Physical Location:

34710092-34730275 on NC_000074.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5516 Symbol (Name): PPP2CB (protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform)

Ortholog Status:

The human GeneID 5516 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Ppp2cb
Original ID2:		Z67746

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws3/Alcw6	Chronic Alcohol Withdrawal	8		16-43 (cM)	3.5	0.0003	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_017374.3	NP_059070.1	NC_000074.5 range: 34710092..34730275

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000159	protein phosphatase type 2A complex	Cellular Component	IDA (16717086)
GO:0005634	nucleus	Cellular Component	TAS (10781942)
GO:0005737	cytoplasm	Cellular Component	IDA (10781942)
GO:0030145	manganese ion binding	Molecular Function	RCA (12466851)
GO:0017018	myosin phosphatase activity	Molecular Function	RCA (12466851)
GO:0016787	hydrolase activity	Molecular Function	RCA (12466851)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0008420	CTD phosphatase activity	Molecular Function	RCA (12466851)
GO:0005515	protein binding	Molecular Function	IPI (12885400\|16717086)
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0004722	protein serine/threonine phosphatase activity	Molecular Function	RCA (12466851)
GO:0004721	phosphoprotein phosphatase activity	Molecular Function	IEA
GO:0006470	protein amino acid dephosphorylation	Biological Process	RCA (12466851)
GO:0046677	response to antibiotic	Biological Process	IMP (16717086)
GO:0043161	proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IMP (16717086)
GO:0043066	negative regulation of apoptosis	Biological Process	IMP (16717086)
GO:0042542	response to hydrogen peroxide	Biological Process	IMP (16717086)
GO:0042221	response to chemical stimulus	Biological Process	IMP (16717086)
GO:0010468	regulation of gene expression	Biological Process	IMP (16717086)