ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PPP2CB

Full Name:

protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform

Alias:

PP2CB

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

8p12

Physical Location:

30762667-30789893 on NC_000008.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 19053 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.491440
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000159	protein phosphatase type 2A complex	Cellular Component	TAS (8206937)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0004722	protein serine/threonine phosphatase activity	Molecular Function	TAS (8206937)
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (17353931)
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0030145	manganese ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006470	protein amino acid dephosphorylation	Biological Process	TAS (2849765)