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Gene Information
Gene ID:5516
Symbol:PPP2CB
Full Name:protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
Alias:PP2CB
Organism:Homo sapiens (Human)
Chromosome:8
Genetic Location:8p12
Physical Location:30762667-30789893 on NC_000008.9, complement
Gene Type:protein-coding
Orthologs:This gene has Mouse: 19053 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.491440
Note:"Class II, down-regulated gene"
Dataset Information
Name:16292326
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001009552.1NP_001009552.1NC_000008.9 range: 30762667..30789893, complement
NM_004156.2NP_004147.1NC_000008.9 range: 30762667..30789893, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000159protein phosphatase type 2A complexCellular ComponentTAS (8206937)
GO:0005737cytoplasmCellular ComponentIEA
GO:0004722protein serine/threonine phosphatase activityMolecular FunctionTAS (8206937)
GO:0005506iron ion bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (17353931)
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0030145manganese ion bindingMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0006470protein amino acid dephosphorylationBiological ProcessTAS (2849765)
Other Database Cross Links
NCBI Entrez Gene:5516
HGNC:9300
Ensembl:ENSG00000104695
MIM:176916
HPRD:01487
HuGE Navigator:5516
dbSNP:PPP2CB
GeneCard:PPP2CB
AceView:PPP2CB