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Gene Information
Gene ID:20716
Full Name:serine (or cysteine) peptidase inhibitor, clade A, member 3N
Organism:Mus musculus (Mouse)
Genetic Location:12 F1
Physical Location:105644917-105652538 on NC_000078.5
Gene Type:protein-coding
Human Ortholog:GeneID: 12    Symbol (Name): SERPINA3 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3)
Ortholog Status:The human GeneID 12 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Serpina3n
Original ID2:M64086
Dataset Information
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_009252.2NP_033278.2NC_000078.5 range: 105644917..105652538
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005576extracellular regionCellular ComponentIEA
GO:0005615extracellular spaceCellular ComponentRCA (12466851)
GO:0004866endopeptidase inhibitor activityMolecular FunctionIEA
GO:0004867serine-type endopeptidase inhibitor activityMolecular FunctionIEA
GO:0006953acute-phase responseBiological ProcessIEA
GO:0008150biological_processBiological ProcessND
Other Database Cross Links
NCBI Entrez Gene:20716