ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pkp4

Full Name:

plakophilin 4

Alias:

5031422I09Rik|9430019K17Rik|Armrp|MGC100358|MGC105166|p0071

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

2 C3

Physical Location:

58999076-59193259 on NC_000068.6

Gene Type:

protein-coding

Human Ortholog:

GeneID: 8502 Symbol (Name): PKP4 (plakophilin 4)

Ortholog Status:

The human GeneID 8502 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Pkp4
Original ID2:		AI837021

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_026361.2	NP_080637.1	NC_000068.6 range: 58999076..59193259

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005856	cytoskeleton	Cellular Component	IEA
GO:0030054	cell junction	Cellular Component	IEA
GO:0005198	structural molecule activity	Molecular Function	IEA
GO:0005488	binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0007155	cell adhesion	Biological Process	IEA