ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

FOS

Full Name:

v-fos FBJ murine osteosarcoma viral oncogene homolog

Alias:

AP-1|C-FOS

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

14q24.3

Physical Location:

74815283-74818665 on NC_000014.7

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 314322 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

FOS

Dataset Information

Name:		18477577
Method:		Addiction array gene list
Publication:		Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
Summary:		To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_005252.2	NP_005243.1	NC_000014.7 range: 74815283..74818665

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	TAS (9443941)
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0003704	specific RNA polymerase II transcription factor activity	Molecular Function	TAS (10918580)
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0046983	protein dimerization activity	Molecular Function	IEA
GO:0006306	DNA methylation	Biological Process	TAS (9888853)
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	TAS (10918580)
GO:0006954	inflammatory response	Biological Process	TAS (9443941)