ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Fos

Full Name:

FBJ osteosarcoma oncogene

Alias:

c-fos

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

6q31

Physical Location:

109559153-109562545 on NC_005105.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2353 Symbol (Name): FOS (v-fos FBJ murine osteosarcoma viral oncogene homolog)

Ortholog Status:

The human GeneID 2353 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Fos
Fold Change:		1.52
P Value:		0.003
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_022197.2	NP_071533.1	NC_005105.2 range: 109559153..109562545

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005667	transcription factor complex	Cellular Component	ISS
GO:0005634	nucleus	Cellular Component	TAS (11025764)
GO:0005634	nucleus	Cellular Component	ISS
GO:0005634	nucleus	Cellular Component	IDA (10830307)
GO:0005667	transcription factor complex	Cellular Component	IEA
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0003677	DNA binding	Molecular Function	IDA (2105492)
GO:0046982	protein heterodimerization activity	Molecular Function	IC (10830307)
GO:0046982	protein heterodimerization activity	Molecular Function	IDA (2105492)
GO:0046982	protein heterodimerization activity	Molecular Function	IPI (9369238)
GO:0043565	sequence-specific DNA binding	Molecular Function	IDA (10830307)
GO:0003700	transcription factor activity	Molecular Function	TAS (2105492)
GO:0003677	DNA binding	Molecular Function	ISS
GO:0003690	double-stranded DNA binding	Molecular Function	IDA (2105492\|10830307)
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	IMP (10830307)
GO:0003700	transcription factor activity	Molecular Function	ISS
GO:0046983	protein dimerization activity	Molecular Function	IEA
GO:0007399	nervous system development	Biological Process	ISS
GO:0007399	nervous system development	Biological Process	IEA
GO:0006366	transcription from RNA polymerase II promoter	Biological Process	IMP (10830307)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	ISS
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA