ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

24186

Symbol:

Alb

Full Name:

albumin

Alias:

Alb1|Albza

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

14p22

Physical Location:

19126964-19142198 on NC_005113.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 213 Symbol (Name): ALB (albumin)

Ortholog Status:

The human GeneID 213 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Alb
Fold Change:		1.21
P Value:		0.005
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Gene Information

Original ID1:		Alb
Fold Change:		1.22
P Value:		0.001
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Gene Information

Original ID1:		Alb
Fold Change:		1.35
P Value:		0
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_134326.2	NP_599153.2	NC_005113.2 range: 19126964..19142198, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005615	extracellular space	Cellular Component	IDA (17010194)
GO:0005615	extracellular space	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005604	basement membrane	Cellular Component	IDA (1723977)
GO:0005576	extracellular region	Cellular Component	ISS
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0043234	protein complex	Cellular Component	ISS
GO:0005615	extracellular space	Cellular Component	ISS
GO:0019825	oxygen binding	Molecular Function	ISS
GO:0019825	oxygen binding	Molecular Function	ISS
GO:0003677	DNA binding	Molecular Function	ISS
GO:0030170	pyridoxal phosphate binding	Molecular Function	ISS
GO:0043498	cell surface binding	Molecular Function	IDA (2542333)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0015643	toxin binding	Molecular Function	ISS
GO:0008270	zinc ion binding	Molecular Function	IDA (540055)
GO:0005504	fatty acid binding	Molecular Function	IDA (16753933)
GO:0008144	drug binding	Molecular Function	ISS
GO:0008144	drug binding	Molecular Function	IPI (12458670)
GO:0005515	protein binding	Molecular Function	ISS
GO:0005504	fatty acid binding	Molecular Function	ISS
GO:0005507	copper ion binding	Molecular Function	IEA
GO:0009267	cellular response to starvation	Biological Process	ISS
GO:0046689	response to mercury ion	Biological Process	IEP (17184894)
GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep	Biological Process	IDA (9748091)
GO:0043066	negative regulation of apoptosis	Biological Process	ISS
GO:0042311	vasodilation	Biological Process	NAS (11983891)
GO:0019836	hemolysis by symbiont of host red blood cells	Biological Process	ISS
GO:0006810	transport	Biological Process	IEA
GO:0010033	response to organic substance	Biological Process	IEP (12051991)
GO:0051659	maintenance of mitochondrion localization	Biological Process	ISS