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Gene Information
Gene ID:24245
Full Name:calcium/calmodulin-dependent protein kinase II, beta
Organism:Rattus norvegicus (Rat)
Genetic Location:14q21
Physical Location:86634689-86721260 on NC_005113.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 816    Symbol (Name): CAMK2B (calcium/calmodulin-dependent protein kinase (CaM kinase) II beta)
Ortholog Status:The human GeneID 816 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:24245
Fold Change:0.919
P Value:0.0115
Note:Fold change is average ratio of AA to ANA.
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.
Gene Information
Original ID1:Camk2b
Fold Change:1.1
P Value:0.009
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_021739.2NP_068507.2NC_005113.2 range: 86634689..86721260, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005954calcium- and calmodulin-dependent protein kinase complexCellular ComponentTAS
GO:0005524ATP bindingMolecular FunctionIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0004674protein serine/threonine kinase activityMolecular FunctionIEA
GO:0004674protein serine/threonine kinase activityMolecular FunctionISS
GO:0004683calmodulin-dependent protein kinase activityMolecular FunctionIEA
GO:0005516calmodulin bindingMolecular FunctionIEA
GO:0016740transferase activityMolecular FunctionIEA
GO:0016301kinase activityMolecular FunctionIEA
GO:0006816calcium ion transportBiological ProcessISS
GO:0006468protein amino acid phosphorylationBiological ProcessIEA
GO:0000082G1/S transition of mitotic cell cycleBiological ProcessISS
GO:0046777protein amino acid autophosphorylationBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:24245