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Gene Information
Gene ID:24379
Symbol:Gad1
Full Name:glutamic acid decarboxylase 1
Alias:Gad67
Organism:Rattus norvegicus (Rat)
Chromosome:3
Genetic Location:3q21
Physical Location:52789369-52830037 on NC_005102.2
Gene Type:protein-coding
Human Ortholog:GeneID: 2571    Symbol (Name): GAD1 (glutamate decarboxylase 1 (brain, 67kDa))
Ortholog Status:The human GeneID 2571 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Rn.91245
Original ID2:Gad1
Fold Change:1.23
P Value:0.00041
Note:Lower levels in the hippocampus of iP than iNP rats
Dataset Information
Name:15660665
Method:Microarray
Tissue:Hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).
Gene Information
Original ID1:Gad1
Fold Change:-1.25
P Value:0.003
Note:Differential expression between ethanol and water groups in nucleus accumbens
Gene Information
Original ID1:Gad1
Fold Change:-1.23
P Value:0.006
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_017007.1NP_058703.1NC_005102.2 range: 52789369..52830037
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0045202synapseCellular ComponentISS
GO:0030424axonCellular ComponentISS
GO:0005622intracellularCellular ComponentISS
GO:0005737cytoplasmCellular ComponentISS
GO:0005739mitochondrionCellular ComponentISS
GO:0030170pyridoxal phosphate bindingMolecular FunctionIEA
GO:0016829lyase activityMolecular FunctionIEA
GO:0004351glutamate decarboxylase activityMolecular FunctionIDA (1924335)
GO:0005515protein bindingMolecular FunctionISS
GO:0004351glutamate decarboxylase activityMolecular FunctionISS
GO:0004351glutamate decarboxylase activityMolecular FunctionIEA
GO:0019752carboxylic acid metabolic processBiological ProcessIEA
GO:0042136neurotransmitter biosynthetic processBiological ProcessIEA
GO:0007268synaptic transmissionBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:24379
RGD:2652
Ensembl:ENSRNOG00000000007
dbSNP:Gad1