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Gene Information
Gene ID:24380
Full Name:glutamic acid decarboxylase 2
Organism:Rattus norvegicus (Rat)
Genetic Location:17q12.3
Physical Location:96259427-96321856 on NC_005116.2
Gene Type:protein-coding
Human Ortholog:GeneID: 2572    Symbol (Name): GAD2 (glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa))
Ortholog Status:The human GeneID 2572 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:24380
Fold Change:0.764
P Value:0.0485
Note:Fold change is average ratio of AA to ANA.
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.
Gene Information
Original ID1:Gad2
Fold Change:-1.32
P Value:0.007
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012563.1NP_036695.1NC_005116.2 range: 96259427..96321856
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0048471perinuclear region of cytoplasmCellular ComponentIDA (8132714)
GO:0045202synapseCellular ComponentISS
GO:0031410cytoplasmic vesicleCellular ComponentIDA (8132714)
GO:0031225anchored to membraneCellular ComponentIDA (8132714)
GO:0030672synaptic vesicle membraneCellular ComponentIDA (8999827)
GO:0030424axonCellular ComponentISS
GO:0016829lyase activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0004351glutamate decarboxylase activityMolecular FunctionIEA
GO:0004351glutamate decarboxylase activityMolecular FunctionIDA (8999827)
GO:0007268synaptic transmissionBiological ProcessTAS (8999827)
GO:0006540glutamate decarboxylation to succinateBiological ProcessIDA (8999827)
Other Database Cross Links
NCBI Entrez Gene:24380