ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Grm1

Full Name:

glutamate receptor, metabotropic 1

Alias:

Gprc1a

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

1p13

Physical Location:

5318616-5744592 on NC_005100.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2911 Symbol (Name): GRM1 (glutamate receptor, metabotropic 1)

Ortholog Status:

The human GeneID 2911 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Grm1
Fold Change:		-1.19
P Value:		0
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_017011.1	NP_058707.1	NC_005100.2 range: 5318616..5744592, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0014069	postsynaptic density	Cellular Component	ISS
GO:0030425	dendrite	Cellular Component	ISS
GO:0005887	integral to plasma membrane	Cellular Component	TAS (12562994)
GO:0005792	microsome	Cellular Component	ISS
GO:0005634	nucleus	Cellular Component	ISS
GO:0005515	protein binding	Molecular Function	ISS
GO:0004930	G-protein coupled receptor activity	Molecular Function	TAS (12514201)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0008066	glutamate receptor activity	Molecular Function	TAS (12514201)
GO:0008067	metabotropic glutamate, GABA-B-like receptor activity	Molecular Function	IEA
GO:0019722	calcium-mediated signaling	Biological Process	IDA (15229243)
GO:0043408	regulation of MAPKKK cascade	Biological Process	ISS
GO:0000186	activation of MAPKK activity	Biological Process	ISS
GO:0019233	sensory perception of pain	Biological Process	IEP (12514201)
GO:0007626	locomotory behavior	Biological Process	ISS
GO:0007268	synaptic transmission	Biological Process	IEP (12514201)
GO:0000187	activation of MAPK activity	Biological Process	ISS
GO:0051930	regulation of sensory perception of pain	Biological Process	ISS