ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

GRM1

Full Name:

glutamate receptor, metabotropic 1

Alias:

GPRC1A|GRM1A|MGLUR1|MGLUR1A|mGlu1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

6q24

Physical Location:

146392111-146800426 on NC_000006.10

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 24414 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

GRM1

Dataset Information

Name:		18477577
Method:		Addiction array gene list
Publication:		Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
Summary:		To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000838.3	NP_000829.2	NC_000006.10 range: 146392111..146800426

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0005887	integral to plasma membrane	Cellular Component	TAS (7476890)
GO:0008067	metabotropic glutamate, GABA-B-like receptor activity	Molecular Function	TAS (7476890)
GO:0008067	metabotropic glutamate, GABA-B-like receptor activity	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0007268	synaptic transmission	Biological Process	TAS (9076744)
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IEA
GO:0007165	signal transduction	Biological Process	IEA
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	TAS (7476890)