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Gene Information
Gene ID:24680
Full Name:protein kinase C, alpha
Organism:Rattus norvegicus (Rat)
Genetic Location:10q32.1
Physical Location:97366772-97625117 on NC_005109.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 5578    Symbol (Name): PRKCA (protein kinase C, alpha)
Ortholog Status:The human GeneID 5578 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Prkca
Fold Change:-1.12
P Value:0.009
Note:Differential expression between ethanol and water groups in nucleus accumbens
Gene Information
Original ID1:Prkca
Fold Change:-1.17
P Value:0.001
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
XM_343975.3XP_343976.3NC_005109.2 range: 97366772..97625117, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005624membrane fractionCellular ComponentISS
GO:0005624membrane fractionCellular ComponentIDA (16837815)
GO:0005634nucleusCellular ComponentISS
GO:0005737cytoplasmCellular ComponentISS
GO:0005739mitochondrionCellular ComponentISS
GO:0005829cytosolCellular ComponentIDA (16837815)
GO:0005829cytosolCellular ComponentISS
GO:0005886plasma membraneCellular ComponentIDA (15814842)
GO:0043234protein complexCellular ComponentIDA (11007882)
GO:0019717synaptosomeCellular ComponentIDA (16045453)
GO:0019992diacylglycerol bindingMolecular FunctionIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIPI (16045453)
GO:0016740transferase activityMolecular FunctionIEA
GO:0004674protein serine/threonine kinase activityMolecular FunctionISS
GO:0004697protein kinase C activityMolecular FunctionIDA (15272003)
GO:0004697protein kinase C activityMolecular FunctionIEA
GO:0004697protein kinase C activityMolecular FunctionISS
GO:0004698calcium-dependent protein kinase C activityMolecular FunctionIDA (9046017)
GO:0004698calcium-dependent protein kinase C activityMolecular FunctionISS
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0018105peptidyl-serine phosphorylationBiological ProcessIDA (15272003)
GO:0050930induction of positive chemotaxisBiological ProcessISS
GO:0018107peptidyl-threonine phosphorylationBiological ProcessIDA (15272003)
GO:0050730regulation of peptidyl-tyrosine phosphorylationBiological ProcessISS
GO:0050729positive regulation of inflammatory responseBiological ProcessISS
GO:0030593neutrophil chemotaxisBiological ProcessISS
GO:0048259regulation of receptor-mediated endocytosisBiological ProcessIMP (15272003)
GO:0045184establishment of protein localizationBiological ProcessTAS
GO:0046627negative regulation of insulin receptor signaling pathwayBiological ProcessISS
GO:0046325negative regulation of glucose importBiological ProcessISS
GO:0017148negative regulation of translationBiological ProcessIMP (16556598)
GO:0008629induction of apoptosis by intracellular signalsBiological ProcessISS
GO:0001933negative regulation of protein amino acid phosphorylationBiological ProcessISS
GO:0001934positive regulation of protein amino acid phosphorylationBiological ProcessISS
GO:0002026regulation of the force of heart contractionBiological ProcessISS
GO:0002062chondrocyte differentiationBiological ProcessISS
GO:0006468protein amino acid phosphorylationBiological ProcessIEA
GO:0006468protein amino acid phosphorylationBiological ProcessISS
GO:0006469negative regulation of protein kinase activityBiological ProcessISS
GO:0006874cellular calcium ion homeostasisBiological ProcessISS
GO:0006937regulation of muscle contractionBiological ProcessISS
GO:0007242intracellular signaling cascadeBiological ProcessIDA (11562372)
GO:0007242intracellular signaling cascadeBiological ProcessIEA
GO:0000188inactivation of MAPK activityBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:24680