ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Sdc4

Full Name:

syndecan 4

Alias:

RATRYUDOCA|RYUDOCA

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

3q42

Physical Location:

155446145-155464824 on NC_005102.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6385 Symbol (Name): SDC4 (syndecan 4)

Ortholog Status:

The human GeneID 6385 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Sdc4
Fold Change:		1.17
P Value:		0.009
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012649.2	NP_036781.1	NC_005102.2 range: 155446145..155464824, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005925	focal adhesion	Cellular Component	IDA (12493766)
GO:0045121	membrane raft	Cellular Component	IMP (11889131)
GO:0043034	costamere	Cellular Component	IDA (12209563)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0009986	cell surface	Cellular Component	ISS
GO:0009986	cell surface	Cellular Component	IEA
GO:0008092	cytoskeletal protein binding	Molecular Function	IEA
GO:0051018	protein kinase A binding	Molecular Function	IDA (12571249)
GO:0051393	alpha-actinin binding	Molecular Function	IPI (12493766)
GO:0007267	cell-cell signaling	Biological Process	NAS (12135485)
GO:0007155	cell adhesion	Biological Process	NAS (12135485)
GO:0006937	regulation of muscle contraction	Biological Process	IPI (12209563)
GO:0045860	positive regulation of protein kinase activity	Biological Process	IMP (12571249)