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Gene Information
Gene ID:24888
Full Name:Bcl2-like 1
Organism:Rattus norvegicus (Rat)
Genetic Location:3q41.2
Physical Location:143129086-143180198 on NC_005102.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 598    Symbol (Name): BCL2L1 (BCL2-like 1)
Ortholog Status:The human GeneID 598 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:24888
Fold Change:1.376
P Value:0.0015
Note:Fold change is average ratio of AA to ANA.
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.
Gene Information
Original ID1:Bcl2l1
Fold Change:-1.22
P Value:0
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001033670.1NP_001028842.1NC_005102.2 range: 143129086..143180198, complement
NM_001033671.1NP_001028843.1NC_005102.2 range: 143129086..143180198, complement
NM_001033672.1NP_001028844.1NC_005102.2 range: 143129086..143180198, complement
NM_031535.2NP_113723.2NC_005102.2 range: 143129086..143180198, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000299integral to membrane of membrane fractionCellular ComponentTAS (12097494)
GO:0005741mitochondrial outer membraneCellular ComponentIDA (12515824)
GO:0005740mitochondrial envelopeCellular ComponentIDA (12097494)
GO:0005739mitochondrionCellular ComponentISS
GO:0044429mitochondrial partCellular ComponentISS
GO:0005515protein bindingMolecular FunctionIPI (15120593)
GO:0005515protein bindingMolecular FunctionISS
GO:0042802identical protein bindingMolecular FunctionISS
GO:0043027caspase inhibitor activityMolecular FunctionIDA (12097494)
GO:0042542response to hydrogen peroxideBiological ProcessIEP (17869087)
GO:0042981regulation of apoptosisBiological ProcessIDA (12515824)
GO:0042981regulation of apoptosisBiological ProcessIEA
GO:0043066negative regulation of apoptosisBiological ProcessISS
GO:0043434response to peptide hormone stimulusBiological ProcessIEP (17728251)
GO:0043524negative regulation of neuron apoptosisBiological ProcessISS
GO:0045768positive regulation of anti-apoptosisBiological ProcessISS
GO:0046902regulation of mitochondrial membrane permeabilityBiological ProcessISS
GO:0014070response to organic cyclic substanceBiological ProcessIEP (17805306)
GO:0010288response to lead ionBiological ProcessIEP (17912701)
GO:0001541ovarian follicle developmentBiological ProcessIMP (17989359)
GO:0001666response to hypoxiaBiological ProcessIEP (17272823)
GO:0001836release of cytochrome c from mitochondriaBiological ProcessISS
GO:0006915apoptosisBiological ProcessISS
GO:0006916anti-apoptosisBiological ProcessIDA (12097494|12515824)
GO:0006916anti-apoptosisBiological ProcessISS
GO:0006950response to stressBiological ProcessIEP (17700647)
GO:0006979response to oxidative stressBiological ProcessIEP (12721309)
GO:0009314response to radiationBiological ProcessISS
GO:0010035response to inorganic substanceBiological ProcessIEP (18179739)
GO:0010243response to organic nitrogenBiological ProcessIEP (17961945)
GO:0051881regulation of mitochondrial membrane potentialBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:24888