ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Atxn1

Full Name:

ataxin 1

Alias:

Sca1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

17p13

Physical Location:

24719051-25138269 on NC_005116.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6310 Symbol (Name): ATXN1 (ataxin 1)

Ortholog Status:

The human GeneID 6310 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		25049
Fold Change:		0.509
P Value:		0.009
Note:		Fold change is average ratio of AA to ANA.

Dataset Information

Name:		15846778
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:		DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012726.2	NP_036858.1	NC_005116.2 range: 24719051..25138269

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0042272	nuclear RNA export factor complex	Cellular Component	ISS
GO:0016363	nuclear matrix	Cellular Component	ISS
GO:0042405	nuclear inclusion body	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0005654	nucleoplasm	Cellular Component	ISS
GO:0005634	nucleus	Cellular Component	ISS
GO:0005575	cellular_component	Cellular Component	ND
GO:0042272	nuclear RNA export factor complex	Cellular Component	ISS
GO:0016564	transcription repressor activity	Molecular Function	ISS
GO:0034046	poly(rG) binding	Molecular Function	ISS
GO:0042802	identical protein binding	Molecular Function	IEA
GO:0042802	identical protein binding	Molecular Function	ISS
GO:0043621	protein self-association	Molecular Function	ISS
GO:0003674	molecular_function	Molecular Function	ND
GO:0008266	poly(U) binding	Molecular Function	ISS
GO:0008022	protein C-terminus binding	Molecular Function	ISS
GO:0003723	RNA binding	Molecular Function	ISS
GO:0003723	RNA binding	Molecular Function	IEA
GO:0060079	regulation of excitatory postsynaptic membrane potential	Biological Process	IEA
GO:0051168	nuclear export	Biological Process	ISS
GO:0016481	negative regulation of transcription	Biological Process	ISS
GO:0008542	visual learning	Biological Process	ISS
GO:0008542	visual learning	Biological Process	IEA
GO:0008344	adult locomotory behavior	Biological Process	ISS
GO:0008344	adult locomotory behavior	Biological Process	IEA
GO:0008150	biological_process	Biological Process	ND
GO:0060079	regulation of excitatory postsynaptic membrane potential	Biological Process	ISS