ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ATXN1

Full Name:

ataxin 1

Alias:

ATX1|D6S504E|SCA1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

6p23

Physical Location:

16407321-16869699 on NC_000006.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 25049 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

AL009031

Dataset Information

Name:		12065639
Method:		Microarray
Tissue:		Frontal and motor cortices
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
Summary:		We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. Fluorescent intensity ratios of 1.4-fold or greater in either direction (representing the 99% confidence interval) were used to indicate differentially expressed genes.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000332.3	NP_000323.2	NC_000006.10 range: 16407321..16869699, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016363	nuclear matrix	Cellular Component	IDA (17557114)
GO:0005634	nucleus	Cellular Component	IDA (7647801)
GO:0005654	nucleoplasm	Cellular Component	IDA (12757932)
GO:0005737	cytoplasm	Cellular Component	IDA (7647801)
GO:0042272	nuclear RNA export factor complex	Cellular Component	IDA (15615787)
GO:0042405	nuclear inclusion body	Cellular Component	IDA (15615787)
GO:0034046	poly(rG) binding	Molecular Function	IDA (11136710)
GO:0042802	identical protein binding	Molecular Function	IPI (16713569)
GO:0043621	protein self-association	Molecular Function	IDA (9097953)
GO:0016564	transcription repressor activity	Molecular Function	IDA (15016912)
GO:0003723	RNA binding	Molecular Function	IEA
GO:0008266	poly(U) binding	Molecular Function	IDA (11136710)
GO:0008022	protein C-terminus binding	Molecular Function	IPI (12757932\|15016912)
GO:0016481	negative regulation of transcription	Biological Process	IDA (15016912)
GO:0008219	cell death	Biological Process	IEA
GO:0006396	RNA processing	Biological Process	NAS (15615787)
GO:0051168	nuclear export	Biological Process	IDA (15615787)