ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

25125

Symbol:

Stat3

Full Name:

signal transducer and activator of transcription 3

Alias:

MGC93551

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

10q32.1

Physical Location:

89821077-89872969 on NC_005109.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6774 Symbol (Name): STAT3 (signal transducer and activator of transcription 3 (acute-phase response factor))

Ortholog Status:

The human GeneID 6774 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		25125
Fold Change:		1.393
P Value:		0.0285
Note:		Fold change is average ratio of AA to ANA.

Dataset Information

Name:		15846778
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:		DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012747.2	NP_036879.1	NC_005109.2 range: 89821077..89872969, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005886	plasma membrane	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	ISS
GO:0005634	nucleus	Cellular Component	IEA
GO:0016563	transcription activator activity	Molecular Function	ISS
GO:0008134	transcription factor binding	Molecular Function	ISS
GO:0046983	protein dimerization activity	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IEA
GO:0003677	DNA binding	Molecular Function	IDA (8530402)
GO:0003677	DNA binding	Molecular Function	ISS
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	TAS (8530402)
GO:0004871	signal transducer activity	Molecular Function	IEA
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0042593	glucose homeostasis	Biological Process	ISS
GO:0040014	regulation of multicellular organism growth	Biological Process	ISS
GO:0019953	sexual reproduction	Biological Process	ISS
GO:0001754	eye photoreceptor cell differentiation	Biological Process	ISS
GO:0042755	eating behavior	Biological Process	ISS
GO:0007259	JAK-STAT cascade	Biological Process	TAS (8530402)
GO:0007165	signal transduction	Biological Process	IEA
GO:0006953	acute-phase response	Biological Process	IEP (8530402)
GO:0006366	transcription from RNA polymerase II promoter	Biological Process	ISS
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	ISS
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0001659	temperature homeostasis	Biological Process	ISS