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Gene Information
Gene ID:25125
Full Name:signal transducer and activator of transcription 3
Organism:Rattus norvegicus (Rat)
Genetic Location:10q32.1
Physical Location:89821077-89872969 on NC_005109.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 6774    Symbol (Name): STAT3 (signal transducer and activator of transcription 3 (acute-phase response factor))
Ortholog Status:The human GeneID 6774 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:25125
Fold Change:1.393
P Value:0.0285
Note:Fold change is average ratio of AA to ANA.
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012747.2NP_036879.1NC_005109.2 range: 89821077..89872969, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005886plasma membraneCellular ComponentISS
GO:0005737cytoplasmCellular ComponentISS
GO:0005737cytoplasmCellular ComponentIEA
GO:0005634nucleusCellular ComponentISS
GO:0005634nucleusCellular ComponentIEA
GO:0016563transcription activator activityMolecular FunctionISS
GO:0008134transcription factor bindingMolecular FunctionISS
GO:0046983protein dimerization activityMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIEA
GO:0003677DNA bindingMolecular FunctionIDA (8530402)
GO:0003677DNA bindingMolecular FunctionISS
GO:0003700transcription factor activityMolecular FunctionIEA
GO:0003700transcription factor activityMolecular FunctionTAS (8530402)
GO:0004871signal transducer activityMolecular FunctionIEA
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0042593glucose homeostasisBiological ProcessISS
GO:0040014regulation of multicellular organism growthBiological ProcessISS
GO:0019953sexual reproductionBiological ProcessISS
GO:0001754eye photoreceptor cell differentiationBiological ProcessISS
GO:0042755eating behaviorBiological ProcessISS
GO:0007259JAK-STAT cascadeBiological ProcessTAS (8530402)
GO:0007165signal transductionBiological ProcessIEA
GO:0006953acute-phase responseBiological ProcessIEP (8530402)
GO:0006366transcription from RNA polymerase II promoterBiological ProcessISS
GO:0006357regulation of transcription from RNA polymerase II promoterBiological ProcessISS
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0001659temperature homeostasisBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:25125