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Gene Information
Gene ID:25450
Symbol:Gabrb1
Full Name:gamma-aminobutyric acid (GABA-A) receptor, subunit beta 1
Alias:GARB1
Organism:Rattus norvegicus (Rat)
Chromosome:14
Genetic Location:14p11
Physical Location:38530258-39005614 on NC_005113.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 2560    Symbol (Name): GABRB1 (gamma-aminobutyric acid (GABA) A receptor, beta 1)
Ortholog Status:The human GeneID 2560 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Rn.48879
Fold Change:1.57
P Value:0.00023
Note:higher levels in hippocampus of iP than iNP rats
Dataset Information
Name:15660665
Method:Microarray
Tissue:Hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).
Gene Information
Original ID1:Gabrb1
Fold Change:-1.15
P Value:0.003
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012956.1NP_037088.1NC_005113.2 range: 38530258..39005614, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0045211postsynaptic membraneCellular ComponentIEA
GO:0045202synapseCellular ComponentIEA
GO:0030054cell junctionCellular ComponentIEA
GO:0005886plasma membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0031404chloride ion bindingMolecular FunctionIEA
GO:0030594neurotransmitter receptor activityMolecular FunctionIEA
GO:0015276ligand-gated ion channel activityMolecular FunctionTAS (12239220)
GO:0004890GABA-A receptor activityMolecular FunctionIDA (2548852)
GO:0005254chloride channel activityMolecular FunctionIEA
GO:0005230extracellular ligand-gated ion channel activityMolecular FunctionIEA
GO:0005216ion channel activityMolecular FunctionIEA
GO:0004890GABA-A receptor activityMolecular FunctionIEA
GO:0006821chloride transportBiological ProcessTAS (12239220)
GO:0006811ion transportBiological ProcessIEA
GO:0007214gamma-aminobutyric acid signaling pathwayBiological ProcessTAS (11986365)
Other Database Cross Links
NCBI Entrez Gene:25450
RGD:2649
Ensembl:ENSRNOG00000002327
dbSNP:Gabrb1