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Gene Information
Gene ID:25492
Symbol:Nfia
Full Name:nuclear factor I/A
Organism:Rattus norvegicus (Rat)
Chromosome:5
Physical Location:118165237-118508090 on NC_005104.2
Gene Type:protein-coding
Human Ortholog:GeneID: 4774    Symbol (Name): NFIA (nuclear factor I/A)
Ortholog Status:The human GeneID 4774 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Nfia
Fold Change:1.19
P Value:0.007
Note:Differential expression between ethanol and water groups in nucleus accumbens
Gene Information
Original ID1:Nfia
Fold Change:1.2
P Value:0.004
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012988.2NP_037120.1NC_005104.2 range: 118165237..118508090
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005622intracellularCellular ComponentIEA
GO:0005634nucleusCellular ComponentIEA
GO:0005634nucleusCellular ComponentISS
GO:0003677DNA bindingMolecular FunctionISS
GO:0003700transcription factor activityMolecular FunctionIEA
GO:0008134transcription factor bindingMolecular FunctionISS
GO:0006260DNA replicationBiological ProcessIEA
GO:0006350transcriptionBiological ProcessIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:25492
RGD:3170
Ensembl:ENSRNOG00000006966
dbSNP:Nfia