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Gene Information
Gene ID:25652
Symbol:Ptgfr
Full Name:prostaglandin F receptor
Alias:PF2AR
Organism:Rattus norvegicus (Rat)
Chromosome:2
Genetic Location:2q45
Gene Type:protein-coding
Human Ortholog:GeneID: 5737    Symbol (Name): PTGFR (prostaglandin F receptor (FP))
Ortholog Status:The human GeneID 5737 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Rn.54873
Original ID2:Ptgfr
Fold Change:1.44
P Value:0.00002
Note:Lower levels in the hippocampus of iP than iNP rats
Dataset Information
Name:15660665
Method:Microarray
Tissue:Hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).
Gene Information
Original ID1:25652
Fold Change:1.228
P Value:0.0115
Note:Fold change is average ratio of AA to ANA.
Dataset Information
Name:15846778
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005886plasma membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0001584rhodopsin-like receptor activityMolecular FunctionIEA
GO:0004872receptor activityMolecular FunctionIEA
GO:0004958prostaglandin F receptor activityMolecular FunctionIEA
GO:0004960thromboxane receptor activityMolecular FunctionIEA
GO:0007165signal transductionBiological ProcessIEA
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:25652
RGD:3436
Ensembl:
dbSNP:Ptgfr