| Gene Information | | Original ID1: | | Rn.54873 | | Original ID2: | | Ptgfr | | Fold Change: | | 1.44 | | P Value: | | 0.00002 | | Note: | | Lower levels in the hippocampus of iP than iNP rats |
| | Dataset Information | | Name: | | 15660665 | | Method: | | Microarray | | Tissue: | | Hippocampus | | Phenotype: | | Alcohol-preferring, alcohol-nonpreferring | | Publication: | | Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed | | Summary: | | The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01). |
| | Gene Information | | Original ID1: | | 25652 | | Fold Change: | | 1.228 | | P Value: | | 0.0115 | | Note: | | Fold change is average ratio of AA to ANA. |
| | Dataset Information | | Name: | | 15846778 | | Method: | | Microarray | | Tissue: | | Frontal cortex | | Phenotype: | | Alcohol-preferring, alcohol-nonpreferring | | Publication: | | Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed | | Summary: | | DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats. |
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