ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CLIC4

Full Name:

chloride intracellular channel 4

Alias:

CLIC4L|DKFZP566G223|FLJ38640|H1|MTCLIC|huH1|p64H1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

1p36.11

Physical Location:

24944434-25043345 on NC_000001.9

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 29876 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.440544
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_013943.1	NP_039234.1	NC_000001.9 range: 24944434..25043345

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005622	intracellular	Cellular Component	IDA (11256614)
GO:0005625	soluble fraction	Cellular Component	IDA (10793131)
GO:0005737	cytoplasm	Cellular Component	IDA (10793131)
GO:0005902	microvillus	Cellular Component	IDA (10793131)
GO:0015629	actin cytoskeleton	Cellular Component	TAS (12163372)
GO:0031404	chloride ion binding	Molecular Function	IEA
GO:0005244	voltage-gated ion channel activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (10793131)
GO:0005247	voltage-gated chloride channel activity	Molecular Function	IEA
GO:0006821	chloride transport	Biological Process	NAS (10793131)
GO:0030154	cell differentiation	Biological Process	TAS (12163372)
GO:0030336	negative regulation of cell migration	Biological Process	IDA (12163372)
GO:0006811	ion transport	Biological Process	IEA