ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Clic4

Full Name:

chloride intracellular channel 4 (mitochondrial)

Alias:

D0Jmb3|TU-74|mc3s5|mtCLIC

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

4 D3

Physical Location:

134769883-134828674 on NC_000070.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 25932 Symbol (Name): CLIC4 (chloride intracellular channel 4)

Ortholog Status:

The human GeneID 25932 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Clic4
Original ID2:		AI845237

Gene Information

Original ID1:		Clic4
Original ID2:		AI849533

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_013885.2	NP_038913.1	NC_000070.5 range: 134769883..134828674, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	ISS (10593946)
GO:0016020	membrane	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005739	mitochondrion	Cellular Component	IDA (10593946\|14651853)
GO:0005216	ion channel activity	Molecular Function	IEA
GO:0031404	chloride ion binding	Molecular Function	IEA
GO:0005254	chloride channel activity	Molecular Function	ISS (10593946)
GO:0005247	voltage-gated chloride channel activity	Molecular Function	IEA
GO:0005244	voltage-gated ion channel activity	Molecular Function	IEA
GO:0006811	ion transport	Biological Process	IEA
GO:0006821	chloride transport	Biological Process	ISS (10593946)
GO:0006810	transport	Biological Process	IEA