ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Aldh5a1

Full Name:

aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase)

Alias:

Ssadh

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

17p11

Physical Location:

47193669-47216535 on NC_005116.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7915 Symbol (Name): ALDH5A1 (aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase))

Ortholog Status:

The human GeneID 7915 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Aldh5a1
Fold Change:		1.19
P Value:		0.004
Note:		Differential expression between ethanol and water groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
XM_214478.4	XP_214478.4	NC_005116.2 range: 47193669..47216535

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005625	soluble fraction	Cellular Component	IDA (7262085\|12527414)
GO:0005625	soluble fraction	Cellular Component	ISS
GO:0005739	mitochondrion	Cellular Component	IDA (12527414\|12871571)
GO:0004777	succinate-semialdehyde dehydrogenase activity	Molecular Function	IDA (7262085\|12527414\|12871571)
GO:0004777	succinate-semialdehyde dehydrogenase activity	Molecular Function	ISS
GO:0051287	NAD binding	Molecular Function	IDA (7262085\|12527414\|12871571)
GO:0031406	carboxylic acid binding	Molecular Function	IPI (7262085\|12527414)
GO:0009450	gamma-aminobutyric acid catabolic process	Biological Process	ISS
GO:0007417	central nervous system development	Biological Process	ISS
GO:0006105	succinate metabolic process	Biological Process	IDA (7262085\|12527414\|12871571)
GO:0051289	protein homotetramerization	Biological Process	ISS