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Gene Information
Gene ID:291133
Full Name:aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase)
Organism:Rattus norvegicus (Rat)
Genetic Location:17p11
Physical Location:47193669-47216535 on NC_005116.2
Gene Type:protein-coding
Human Ortholog:GeneID: 7915    Symbol (Name): ALDH5A1 (aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase))
Ortholog Status:The human GeneID 7915 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Aldh5a1
Fold Change:1.19
P Value:0.004
Note:Differential expression between ethanol and water groups in amygdala
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
XM_214478.4XP_214478.4NC_005116.2 range: 47193669..47216535
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005625soluble fractionCellular ComponentIDA (7262085|12527414)
GO:0005625soluble fractionCellular ComponentISS
GO:0005739mitochondrionCellular ComponentIDA (12527414|12871571)
GO:0004777succinate-semialdehyde dehydrogenase activityMolecular FunctionIDA (7262085|12527414|12871571)
GO:0004777succinate-semialdehyde dehydrogenase activityMolecular FunctionISS
GO:0051287NAD bindingMolecular FunctionIDA (7262085|12527414|12871571)
GO:0031406carboxylic acid bindingMolecular FunctionIPI (7262085|12527414)
GO:0009450gamma-aminobutyric acid catabolic processBiological ProcessISS
GO:0007417central nervous system developmentBiological ProcessISS
GO:0006105succinate metabolic processBiological ProcessIDA (7262085|12527414|12871571)
GO:0051289protein homotetramerizationBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:291133