ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Polb

Full Name:

polymerase (DNA directed), beta

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

16q12.5

Physical Location:

73864706-73890113 on NC_005115.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5423 Symbol (Name): POLB (polymerase (DNA directed), beta)

Ortholog Status:

The human GeneID 5423 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Polb
Fold Change:		1.21
P Value:		0.01
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_017141.2	NP_058837.2	NC_005115.2 range: 73864706..73890113

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0005876	spindle microtubule	Cellular Component	ISS
GO:0003684	damaged DNA binding	Molecular Function	IDA (12388548)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0008017	microtubule binding	Molecular Function	ISS
GO:0016779	nucleotidyltransferase activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0003887	DNA-directed DNA polymerase activity	Molecular Function	TAS (12388548)
GO:0003887	DNA-directed DNA polymerase activity	Molecular Function	IEA
GO:0006284	base-excision repair	Biological Process	TAS (12388548)
GO:0006290	pyrimidine dimer repair	Biological Process	IDA (12388548)
GO:0006916	anti-apoptosis	Biological Process	ISS
GO:0008219	cell death	Biological Process	ISS
GO:0006287	base-excision repair, gap-filling	Biological Process	ISS