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Gene Information
Gene ID:29240
Full Name:polymerase (DNA directed), beta
Organism:Rattus norvegicus (Rat)
Genetic Location:16q12.5
Physical Location:73864706-73890113 on NC_005115.2
Gene Type:protein-coding
Human Ortholog:GeneID: 5423    Symbol (Name): POLB (polymerase (DNA directed), beta)
Ortholog Status:The human GeneID 5423 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Polb
Fold Change:1.21
P Value:0.01
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_017141.2NP_058837.2NC_005115.2 range: 73864706..73890113
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentISS
GO:0005876spindle microtubuleCellular ComponentISS
GO:0003684damaged DNA bindingMolecular FunctionIDA (12388548)
GO:0016740transferase activityMolecular FunctionIEA
GO:0008017microtubule bindingMolecular FunctionISS
GO:0016779nucleotidyltransferase activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0003887DNA-directed DNA polymerase activityMolecular FunctionTAS (12388548)
GO:0003887DNA-directed DNA polymerase activityMolecular FunctionIEA
GO:0006284base-excision repairBiological ProcessTAS (12388548)
GO:0006290pyrimidine dimer repairBiological ProcessIDA (12388548)
GO:0006916anti-apoptosisBiological ProcessISS
GO:0008219cell deathBiological ProcessISS
GO:0006287base-excision repair, gap-fillingBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:29240