| Gene Information |
| Gene ID: | | 29318 |
| Symbol: | | Ddt |
| Full Name: | | D-dopachrome tautomerase |
| Organism: | | Rattus norvegicus (Rat) |
| Chromosome: | | 20 |
| Genetic Location: | | 20p12 |
| Physical Location: | | 13591784-13594255 on NC_005119.2, complement |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 1652 Symbol (Name): DDT (D-dopachrome tautomerase) |
| Ortholog Status: | | The human GeneID 1652 is also in human dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | Rn.3464 | | Original ID2: | | Ddt | | Fold Change: | | 1.15 | | P Value: | | 0.00631 | | Note: | | Lower levels in the hippocampus of iP than iNP rats |
| | Dataset Information | | Name: | | 15660665 | | Method: | | Microarray | | Tissue: | | Hippocampus | | Phenotype: | | Alcohol-preferring, alcohol-nonpreferring | | Publication: | | Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed | | Summary: | | The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01). |
| | Gene Information | | Original ID1: | | Ddt | | Fold Change: | | 1.14 | | P Value: | | 0.007 | | Note: | | Differential expression between ethanol and saccharin groups in nucleus accumbens |
| | Dataset Information | | Name: | | 18405950 | | Method: | | Microarray | | Tissue: | | Nucleus accumbens and amygdala | | Phenotype: | | Ethanol self-administration, alcohol-preferring | | Publication: | | Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed | | Summary: | | The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005737 | cytoplasm | Cellular Component | IEA | |
| GO:0004167 | dopachrome isomerase activity | Molecular Function | TAS (9285056) | |
| GO:0005515 | protein binding | Molecular Function | ISS | |
| GO:0016829 | lyase activity | Molecular Function | IEA | |
| GO:0033981 | D-dopachrome decarboxylase activity | Molecular Function | IEA | |
| GO:0006583 | melanin biosynthetic process from tyrosine | Biological Process | IEA | |
| GO:0006954 | inflammatory response | Biological Process | NAS (9285056) | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 29318 |
| RGD: | | 61923 |
| Ensembl: | | ENSRNOG00000001239 |
| dbSNP: | | Ddt |
