ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Serinc3

Full Name:

serine incorporator 3

Alias:

MGC94574|Tde1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

3q42

Physical Location:

154539791-154559238 on NC_005102.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 10955 Symbol (Name): SERINC3 (serine incorporator 3)

Ortholog Status:

The human GeneID 10955 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Serinc3
Fold Change:		-1.21
P Value:		0.002
Note:		Differential expression between ethanol and saccharin groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001008312.1	NP_001008313.1	NC_005102.2 range: 154539791..154559238, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005794	Golgi apparatus	Cellular Component	ISS
GO:0005886	plasma membrane	Cellular Component	ISS
GO:0005515	protein binding	Molecular Function	ISS
GO:0015194	L-serine transmembrane transporter activity	Molecular Function	ISS
GO:0006658	phosphatidylserine metabolic process	Biological Process	ISS
GO:0006665	sphingolipid metabolic process	Biological Process	ISS
GO:0006917	induction of apoptosis	Biological Process	ISS
GO:0015825	L-serine transport	Biological Process	ISS
GO:0051347	positive regulation of transferase activity	Biological Process	ISS