ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Vinc

Alias:

CG3299|CT11081|Dmvincp|EG:103B4.1|Vin|Vin2EF

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

2E2-2E3

Physical Location:

2108318-2116491 on NC_004354.3, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7414 Symbol (Name): VCL (vinculin)

Ortholog Status:

The human GeneID 7414 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_057472.2	NP_476820.1	NC_004354.3 range: 2108318..2116491, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005925	focal adhesion	Cellular Component	ISS (10908592)
GO:0015629	actin cytoskeleton	Cellular Component	IEA
GO:0003779	actin binding	Molecular Function	ISS (10908588)
GO:0005198	structural molecule activity	Molecular Function	IEA
GO:0006911	phagocytosis, engulfment	Biological Process	IMP (16336044)
GO:0007016	cytoskeletal anchoring	Biological Process	ISS (10908592)
GO:0007155	cell adhesion	Biological Process	IEA
GO:0007155	cell adhesion	Biological Process	NAS