ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

HNRNPA2B1

Full Name:

heterogeneous nuclear ribonucleoprotein A2/B1

Alias:

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

7p15

Physical Location:

26196080-26206937 on NC_000007.12, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 53379 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.487774
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0030530	heterogeneous nuclear ribonucleoprotein complex	Cellular Component	IDA (2557628)
GO:0005681	spliceosome	Cellular Component	IDA (9731529)
GO:0043047	single-stranded telomeric DNA binding	Molecular Function	IDA (15659580)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (16294306)
GO:0003723	RNA binding	Molecular Function	IDA (15659580)
GO:0003676	nucleic acid binding	Molecular Function	IEA
GO:0008380	RNA splicing	Biological Process	IEA
GO:0000398	nuclear mRNA splicing, via spliceosome	Biological Process	IC (9731529)
GO:0000398	nuclear mRNA splicing, via spliceosome	Biological Process	EXP (12226669)
GO:0050658	RNA transport	Biological Process	IDA (17004321)