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Gene Information
Gene ID:33324
Organism:Drosophila melanogaster (Fly)
Genetic Location:22A1-22A1
Physical Location:1359982-1361731 on NT_033779.4, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 347    Symbol (Name): APOD (apolipoprotein D)
Ortholog Status:The human GeneID 347 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:NLaz
P Value:1.73E-02
Note:Slow down-regulation, have human and mouse orthologs.
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_175946.1NP_787960.1NT_033779.4 range: 1359982..1361731, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005615extracellular spaceCellular ComponentIDA (10949044)
GO:0005215transporter activityMolecular FunctionIEA
GO:0005488bindingMolecular FunctionNAS
GO:0008289lipid bindingMolecular FunctionISS
GO:0006810transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:33324