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Gene Information
Gene ID:347
Full Name:apolipoprotein D
Organism:Homo sapiens (Human)
Genetic Location:3q26.2-qter
Physical Location:196776864-196792277 on NC_000003.10, complement
Gene Type:protein-coding
Orthologs:This gene has Mouse: 11815 Fly: 33324 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AI188519
Dataset Information
Tissue:Frontal and motor cortices
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
Summary:We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. Fluorescent intensity ratios of 1.4-fold or greater in either direction (representing the 99% confidence interval) were used to indicate differentially expressed genes.
Gene Information
Original ID1:AA131720
Fold Change:0.61
P Value:4.00E-03
Tissue:Prefrontal cortex
Dataset Information
Tissue:Prefrontal cortex and nucleus accumbens
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.
Gene Information
Original ID1:APOD
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001647.2NP_001638.1NC_000003.10 range: 196776864..196792277, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005615extracellular spaceCellular ComponentTAS (3453108)
GO:0005576extracellular regionCellular ComponentNAS (14718574)
GO:0008035high-density lipoprotein bindingMolecular FunctionNR
GO:0005215transporter activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (7918467)
GO:0005501retinoid bindingMolecular FunctionIEA
GO:0005319lipid transporter activityMolecular FunctionTAS (3453108)
GO:0008289lipid bindingMolecular FunctionIEA
GO:0006629lipid metabolic processBiological ProcessTAS (3453108)
GO:0006810transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:347
HuGE Navigator:347