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Gene Information
Gene ID:33435
Organism:Drosophila melanogaster (Fly)
Genetic Location:22F4-22F4
Physical Location:2492954-2498845 on NT_033779.4
Gene Type:protein-coding
Human Ortholog:GeneID: 220323    Symbol (Name): OAF (OAF homolog (Drosophila))
Ortholog Status:The human GeneID 220323 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:oaf
P Value:3.34E-02
Note:Acute up-regulation, have human and mouse orthologs.
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_057692.2NP_477040.1NT_033779.4 range: 2492954..2498845
NM_164489.1NP_722815.1NT_033779.4 range: 2492954..2498845
NM_164490.1NP_722816.1NT_033779.4 range: 2492954..2498845
NM_175949.1NP_787963.2NT_033779.4 range: 2492954..2498845
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0007399nervous system developmentBiological ProcessNAS
GO:0007562eclosionBiological ProcessNAS
GO:0016321female meiosis chromosome segregationBiological ProcessIMP (11290718)
Other Database Cross Links
NCBI Entrez Gene:33435