ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

oaf

Alias:

CG9884|l(2)22Fb|l(2)ND1|tnd

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

22F4-22F4

Physical Location:

2492954-2498845 on NT_033779.4

Gene Type:

protein-coding

Human Ortholog:

GeneID: 220323 Symbol (Name): OAF (OAF homolog (Drosophila))

Ortholog Status:

The human GeneID 220323 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		oaf
P Value:		3.34E-02
Note:		Acute up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0007399	nervous system development	Biological Process	NAS
GO:0007562	eclosion	Biological Process	NAS
GO:0016321	female meiosis chromosome segregation	Biological Process	IMP (11290718)