ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CG1516

Alias:

BcDNA|BcDNA:GH06348

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

46B4-46B4

Physical Location:

5738212-5749047 on NT_033778.3, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5091 Symbol (Name): PC (pyruvate carboxylase)

Ortholog Status:

The human GeneID 5091 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		CG1516
P Value:		2.46E-02
Note:		Acute up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005759	mitochondrial matrix	Cellular Component	ISS
GO:0005811	lipid particle	Cellular Component	IDA (16543254)
GO:0004736	pyruvate carboxylase activity	Molecular Function	ISS
GO:0005524	ATP binding	Molecular Function	IEA
GO:0009374	biotin binding	Molecular Function	IEA
GO:0006090	pyruvate metabolic process	Biological Process	ISS
GO:0006094	gluconeogenesis	Biological Process	IEA