ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

TER94

Alias:

22.26|7.12|Apple|BcDNA.GM02885|BcDNA:GM02885|CG2331|DmTER94|I|Vcp|anon-WO2004063362.65|anon-WO2004063362.67|l(2)03775|l(2)46CFf|l(2)46CFs|l(2)46Ch|unnamed

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

46D1-46D1

Physical Location:

5876665-5881071 on NT_033778.3

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7415 Symbol (Name): VCP (valosin-containing protein)

Ortholog Status:

The human GeneID 7415 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		TER94
P Value:		4.43E-02
Note:		Slow up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001103779.1	NP_001097249.1	NT_033778.3 range: 5876665..5881071
NM_001103780.1	NP_001097250.1	NT_033778.3 range: 5876665..5881071
NM_058021.3	NP_477369.1	NT_033778.3 range: 5876665..5881071
NM_165726.1	NP_724866.1	NT_033778.3 range: 5876665..5881071

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005811	lipid particle	Cellular Component	IDA
GO:0000502	proteasome complex	Cellular Component	NAS (15899868)
GO:0005783	endoplasmic reticulum	Cellular Component	NAS
GO:0045169	fusome	Cellular Component	NAS (11131529)
GO:0004176	ATP-dependent peptidase activity	Molecular Function	IEA
GO:0004252	serine-type endopeptidase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0016887	ATPase activity	Molecular Function	NAS
GO:0017111	nucleoside-triphosphatase activity	Molecular Function	IEA
GO:0042052	rhabdomere development	Biological Process	IMP
GO:0000226	microtubule cytoskeleton organization and biogenesis	Biological Process	IMP (10656772)
GO:0016320	endoplasmic reticulum membrane fusion	Biological Process	ISS (10656772)
GO:0008104	protein localization	Biological Process	IMP
GO:0008103	oocyte microtubule cytoskeleton polarization	Biological Process	IMP
GO:0007317	regulation of pole plasm oskar mRNA localization	Biological Process	IMP (10656772)
GO:0007030	Golgi organization and biogenesis	Biological Process	IMP (10656772)
GO:0007029	endoplasmic reticulum organization and biogenesis	Biological Process	IMP (10656772)
GO:0006508	proteolysis	Biological Process	IMP (15899868)
GO:0045451	pole plasm oskar mRNA localization	Biological Process	IMP